Ssa Antibody Reference Range

Ss a ro antibodies occur in patients with several different connective tissue.

Ssa antibody reference range.

Patients with ss a may also have antibodies to cardiolipin lupus anticoagulant and clinical thromboses. Ss a ro antibodies occur in patients with several different connective tissue diseases including sjogren syndrome an autoimmune disease that involves primarily the salivary and lachrymal glands up to 90 of cases. The reference range of anti ro antibodies is negative. Anti ss a and anti ss b are found in virtually all children with neonatal lupus.

Sjögren s antibody ss b is present only if sjögren s antibody ss a is also detected. Lupus erythematosus le 40 60 of. Ss b la is composed of a 48 kd protein combined with rna species. Sjogren s antibodies ss a ss b sjögren s antibodies ss b is detected in approximately 15 of patients with sjögren s syndrome.

This has been termed antiphospholipid antibody syndrome. Anti ro levels may be elevated in the following conditions. A positive anti ro result is revealed and known by a speckled appearance under immune fluorescence with ultraviolet light. The reference range of anti ro antibodies is negative.

Ss a ro antibodies are associated with childhood le neonatal le and with congenital heart block in infants born to mothers with le 1 2 ss a ro antibodies have also been reported to be associated with features of extraglandular inflammation in patients with le including vasculitis purpura cytopenias and adenopathy. Ss b la antibodies are found primarily in patients with sjogren syndrome or le where they occur with frequencies of approximately 60 and 15 respectively 1 2 ss b la antibodies occur only infrequently in the absence of ss a ro antibodies. Ss a ro ss b la rnp and sm are autoantigens commonly referred to as extractable nuclear antigens ena. Antibodies to ss a are also associated with hla loci dr3 and dr2 and with hereditary deficiency of c2.

Antibodies to ena are common in patients with connective tissue diseases systemic rheumatic diseases. Ss a ro is composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. Ss a ro is an extractable nuclear antigen ena composed of protein antigens of 52 kd and 60 kd combined with cytoplasmic rna species. 60 70 of cases systemic lupus erythematosus sle.